'enables pointer lock options' or 'hardware accelerated video decode'. Try to just run an antivirus-programm to isolate this.
If this is fine, try the following steps to fix issues with Chrome:
If this is not working for you, I would suggest to try some Chrome Browser troubleshooting steps as it might be an issue with that browser: Mhh that sounds weird, normally the game should just stop/pause while leaving the fullscreen and when you come back to that screen you just need to click and the game continues.
